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ea0098c11 | Clinical – Chemo/SSA/Biologics | NANETS2023

Transformation of low-intermediate grade neuroendocrine tumors into high grade morphology

McGlothlin, MD John D. , Dilmaghani, MD Saam , Hazim, MD Antonious Z. , Hobday, MD Timothy J. , Sonbol, MD Mohamad B. , Starr, DO Jason S. , Eiring, PA-C Rachel A. , Graham MBBS Rondell P. , Halfdanarson, MD Thorvardur R.

Background: Low- (G1) and intermediate-grade (G2) neuroendocrine tumors (NET) are defined by lower mitotic rates and genetic mutations that rarely cause transformation to high-grade (G3) neoplasm. Yet a proportion of patients with de novo low-grade NETs progress to G3 disease or even neuroendocrine carcinoma (NEC). We aimed to highlight cases of low-grade G1 and G2 NETs that eventually transformed to G3 pathology on repeat biopsy and describe characteristics that portend high-...

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Transformation of low-intermediate grade neuroendocrine tumors into high grade morphology

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